NovoSorb BTM

The Difference is NovoSorb BTM

NovoSorb® BTM (Biodegradable Temporizing Matrix) is a synthetic, biodegradable and biocompatible device designed to facilitate the dermis to grow within a patented polyurethane matrix. When ready, the sealing membrane is removed, leaving a fully vascularized dermis, ready for definitive closure.

NovoSorb BTM is a bilayer matrix

Feature Product
Sealing membrane

A temporary non-biodegradable layer closes the wound, limiting moisture loss while also serving as a barrier to outside bacteria2,3.

NovoSorb matrix

A 2mm bioabsorbable open cell matrix allows for the infiltration of cellular materials and serves as a matrix to aid in the reconstruction of the deeper layers (dermis) of the skin4.

NovoSorb matrix

A 2mm bioabsorbable open cell matrix allows for the infiltration of cellular materials and serves as a matrix to aid in the reconstruction of the deeper layers (dermis) of the skin4.

The difference is NovoSorb BTM:

  • Robust in the presence of infectionUnlike biologics, NovoSorb BTM’s synthetic composition is not a food supply for bacteria 4
  • Designed to minimize scarring and contractureNovoSorb BTM facilitates the human body to regenerate a neodermis2,5,6
  • Cost effective alternative to biologicstypically less than biologic alternatives
  • No cold storagecan be stored at room temperature (≤ 25° C)
  • Large sizesup to 20x40cm
  • Easy applicationcut and apply with sutures or staples
  • No tissue trackingsaves data logging time for the clinical team


NovoSorb® BTM is indicated for use in the management of wounds including: partial and full thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic and vascular ulcers, surgical wounds (donor sites/grafts, post-Moh’s surgery, post-laser surgery, podiatric, wound dehiscence), trauma wounds (abrasions, lacerations, second-degree burns, and skin tears) and draining wounds.

Phases of NovoSorb BTM Integration

Plus Minus
BTM Work
NovoSorb® BTM implanted into a surgically debrided wound bed

The wound is physiologically closed, limiting the risk of infection, evaporative moisture loss and contraction1,2.

BTM Work
Integration process of NovoSorb® BTM

Over a period of approximately 2 to 3 weeks, NovoSorb® BTM integrates into the wound bed through cellular infltration.

BTM Work
NovoSorb® BTM fully integrated

The dermis is regenerated within the matrix. Once fully integrated, the sealing membrane is ready for removal.

BTM Work
Sealing membrane removed

Once the sealing membrane is removed the neodermis is ready for secondary treatment.

BTM Work
Secondary treatment

Method of secondary treatment is left to the physician’s clinical choice (e.g. closure by SSG, or closure by secondary intent). The NovoSorb® BTM progressively biodegrades and is fully absorbed in approximately 18 months7.

Converting wound repair into regeneration

NovoSorb BTM compartmentalizes a large wound into a series of interconnected microwounds. The body easily heals microwounds, promoting organized regenerative healing.
Normal Healing

The body’s natural reparative process follows the chaotic, unorganized laying down of fibrotic tissue in order to rapidly close the wound. This is followed by months of remodeling and scar contraction.

Healing with NovoSorb BTM

NovoSorb BTM provides a unique matrix for organized healing. Cells and blood vessels migrate into the NovoSorb BTM and a new vascularized dermal-like structure is formed5. The body heals each chamber as a discrete small wound8.

NovoSorb BTM Microarchitecture

NovoSorb BTM is an open cell, non-reticulated matrix with interconnected chambers comprised of an estimated 94.2% open space9. This microstructure is stabilized by struts and the chambers are linked by pores, allowing free flow of fluid.
A photomicrograph of NovoSorb
BTM Microwound
Microarchitecture Feature Icon

The solid structural elements of the matrix

Scanning Electron Microscopic
BTM Microwound
Microarchitecture Feature Icon

The chambers (or cells) highlighted are ~1mm in height

Microarchitecture Feature Icon

Smooth, round connections between two chambers. The pores vary in size and average ~188µm10

The NovoSorb BTM chambers compartmentalize the wound, creating microwounds that the body can heal through regeneration. The chambers create a physical barrier that aids in minimizing the foreign body response and helps prevent encapsulation. As healing progresses, a neodermis develops through the matrix.

Cellular Infiltration and Integration through NovoSorb BTM11

Plus Minus

When applied, NovoSorb BTM is rapidly infiltrated with hemoserous fluid. As cellular migration begins, the chambers are infiltrated by a variety of cell types with the interconnecting pores7 allowing exchange of nutrients and waste. As healing progresses and a neodermis develops through the matrix, the struts hold their shape, maintaining the microstructure into the remodelling phase.

Day 15
  • Cellular activity is seen throughout.
  • Light foreign body response is present without encapsulation.
  • Fibroblasts commence laying down extracellular matrix with low density after 2 weeks.
Day 22
  • extracellular matrix becomes more dense by 3 weeks.
Day 33
  • Signifcant dermal integration is achieved.

Patient Histology7

Plus Green

NovoSorb BTM is designed to facilitate growth, then safely disappear. NovoSorb BTM gradually Hydrolyzes, shrinking and dissipating until fully reabsorbed in approximately 18 months, leaving a healthy, vascularized neodermis7.

Patient at 7 months
Patient Month
Patient Month
Uniform growth of tissue throughout
Patient at 8 months
Patient Month
Patient Month
Macrophages have eaten through smooth wall of polymer Corners are sofening and rounding
Patient at 12 months
Patient Month
Patient Month
NovoSorb BTM FBR almost
completely gone
Fat cells (adipocytes)
Note dissipation of giant cells (lef arrow). Few remnants continue to degrade (right arrow).
Patient at 18 months
Patient Month
NovoSorb BTM is fully hydrolyzed and a fully vascularized neo-dermis remains. Corresponding disappearance of macrophages.
Boxes represent NovoSorb BTM


  • Dearman BL, LiA, Greenwood JE. Optimization of a polyurethane dermal matrix and experience with a polymer-based cultured composite skin. J Burn Care Res. 2014; 35(5): 437-48.
  • Greenwood JE, Dearman BL. Comparison of a sealed, polymer foam biodegradable temporising matrix against Integra(R) dermal regeneration template in a porcine wound model. J Burn Care Res. 2012; 33:163-73.
  • Wagstaff MJD, Schmitt B, Caplash Y, Greenwood JE. Free flap donor site reconstruction: A prospective case series using an optimized polyurethane temporising matrix. Eplasty. 2015; 15:231-48.
  • Greenwood JE, Schmitt BJ, Wagstaff MJD. Experience with a synthetic bilayer Biodegradable temporising Matrix in significant burn injury. Burns Open. 2018;2(1):17-34.
  • Greenwood JE, Dearman BL. Split skin graft application over an integrating, biodegradable temporising polymer matrix: immediate and delayed. J Burn Care Res. 2012; 33:7-19.
  • Wagstaff MJD, Slana IM, Caplash Y, Greenwood JE. Biodegradable temporising Matrix (BTM) for the reconstruction of defects following serial debridement for necrotising fasciitis: A case series. Burns Open. 2019; 3:12-30.
  • Wagstaff MJD, Schmitt BJ, Coghlan P, Finkemeyer JP, Caplash Y, Greenwood JE. A biodegradable polyurethane dermal matrix in reconstruction of free flap donor sites: a pilot study. ePlasty 2015; 15:102-18.
  • Greenwood JE, Wagstaff MJD (2016) The use of biodegradable polyurethane in the development of dermal scaffolds. In: Cooper SL, Guan J (eds) Advances in Polyurethane Materials. 1st edn. Woodhead Publishing, pp 631-62.
  • Data on file TD-114.
  • Internal testing.
  • Data on file: Punch biopsies.